More good news for dogs

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    Breakthrough discovery leads
    to powerful genetic test

    The challenge was posed nearly forty years
    ago; the trail has been hot for the last two.
    Long-standing partnerships have resulted in
    advances in diagnosing and understanding
    hip dysplasia in dogs, a disease that occurs
    when a specific combination of genes
    exists and results in hip osteoarthritis and
    Research indicates that, in addition to
    Labrador Retrievers, discoveries in the diagnosis
    and treatment of hip dysplasia will
    assist other breeds including Border Collies,
    Golden Retrievers, Great Danes, Rottweilers,
    German Shepherds and Newfoundland
    dogs, and has the potential to offer insights
    into similar diseases in other mammals.
    In 2007, with grant support from the Morris
    Animal Foundation and Pfizer Incorporated,
    Dr. George Lust and colleagues Dr.
    Rory Todhunter, Steven Friedenberg and Dr.
    Zhiwu Zhang discovered the first panel of
    genetic markers that could lead to genetic
    testing for the diagnosis of canine hip
    dysplasia. With a new sample of dogs, they
    plan to verify the accuracy of this panel of
    genetic markers for hip conformation that
    can predict the breeding value of the dog.
    A breakthrough in diagnosis, these genetic
    tests are expected to be more accurate
    than current procedures, less expensive to
    perform, and enable earlier identification of
    both normal dogs and those at risk for hip
    dysplasia. Genetic tests may also reduce the
    need for progeny testing.
    “This has been a long-sought goal,” says
    Dr. Lust. “Now, with one DNA sample we
    are on the road to telling if a young dog
    will develop normally. We will not need to
    wait until the dog is old enough to undergo
    the current radiographic screening.”
    The research team also identified a mutation
    in the gene for fibrillin 2 that segregates
    in a sample of dysplastic dogs and
    nondysplastic dogs. Fibrillin 2 is a gene expressed
    in the tissue o f hip joints. This is the
    first gene reported to be associated with
    canine hip dysplasia. The discovery opens
    opportunities for defining the biochemical
    basis of the disease.
    In other related research, Dr. Lust partnered
    with Dr. Bernard G. Steinetz at the New
    York University Medical Center to study the
    relationship of two milk-borne hormones—
    relaxin and estrogen—to the onset of hip
    dysplasia. In a controlled study, the investigators
    concluded that early anti-hormone
    treatments may be able to negate the
    effects of the milk-borne hormones as they
    relate to induction of canine hip dysplasia.

    More here-


    Sounds good :yes:

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